β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action

J Xiang, M Ipek, V Suri, M Tam, Y Xing, N Huang…

Index: Xiang, Jason; Ipek, Manus; Suri, Vipin; Tam, May; Xing, Yuzhe; Huang, Nelson; Zhang, Yanling; Tobin, James; Mansour, Tarek S.; McKew, John Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4396 - 4405

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Citation Number: 46

Abstract

The design, synthesis, and biological evaluation of β-keto sulfones as 11β-HSD1 inhibitors and the mechanism of inhibition are described here. This class of compounds is not active against 11β-HSD2 and therefore may have therapeutic potential for metabolic syndrome and type 2 diabetes.