The Journal of organic chemistry

Ketyl-allene cyclizations promoted by samarium (II) iodide

GA Molander, EP Cormier

Index: Molander, Gary A.; Cormier, Elizabeth Pollina Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2622 - 2626

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Citation Number: 51

Abstract

Samarium (II) iodide has proven to be an effective reagent for intramolecular reductive coupling reactions. Previous investigations of intramolecular ketyl-olefin coupling reactions provided carbocycles in excellent yield and good diastereoselectivity. This method has been extended to ketyl cyclizations with allenes. Substrates leading to both carbocycles and heterocycles in a selective manner are explored.