Chemical Communications

Direct N-alkylation of amino-azoles with alcohols catalyzed by an iridium complex/base system

F Li, H Shan, L Chen, Q Kang, P Zou

Index: Li, Feng; Shan, Haixia; Chen, Lin; Kang, Qikai; Zou, Po Chemical Communications, 2012 , vol. 48, # 4 p. 603 - 605

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Citation Number: 44

Abstract

Amino-azoles are very important structural units in many natural products and other biologically active compounds. In particular, 2-N-(alkylamino)azoles exhibit a wide range of pharmacological and physiological activities. For example, some of them are used as anti-inflammatory agents (Fanetizole A), UDP-galactopyranose mutase inhibitors (B), 1a κ and μ opioid receptors (C) 1b and small-molecule somatostatin receptor subtype 5 (SST5R) antagonists (D) 1c ...