4-Hydroxy-2-quinolones 126. 1-Hydroxy-3-oxo-5, 6-dihydro-3H-pyrrolo [3, 2, 1-ij] quinoline-2-carboxylic acid hydrazide and its derivatives

…, AA Tkach, EV Mospanova, EN Svechnikova

Index: Ukrainets; Tkach; Mospanova; Svechnikova Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 8 p. 1014 - 1019

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Abstract

A preparative method has been developed for the synthesis of 1-hydroxy-3-oxo-5,6-dihydro- 3H pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hydrazide and its derivatives. The results of a study of the antitubercular activity of the synthesized compounds are presented. ... Keywords: 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids, amidation, hydrazinolysis, antitubercular activity. ... Hydrazine derivatives occupy a special place in the chemotherapy of ...