A series of non-quinoline cysLT 1 receptor antagonists: Sar study on pyridyl analogs of singulair®

…, M McAuliffe, C McFarlane, KM Metters, P Prasit…

Index: Guay, Daniel; Gauthier; Dufresne; Jones; McAuliffe; McFarlane; Metters; Prasit; Rochette; Roy; Sawyer; Zamboni Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 5 p. 453 - 458

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Citation Number: 8

Abstract

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair®) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L- 733,321) as an optimized candidate.