Development of a scaleable route for the production of cis-N-benzyl-3-methylamino-4-methylpiperidine

DHB Ripin, S Abele, W Cai, T Blumenkopf…

Index: Organic Process Research and Development, , vol. 7, # 1 p. 115 - 120

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Citation Number: 29

Abstract

... Route Modification To Develop a Scaleable Process. ... material from the Oxone oxidation evolved only small amounts of hydrogen in the same salt-forming procedure. ... After workup, nitrogen was sparged through the organic phase containing the ketone via an immersed tube at 50 ...

Efficient and Chemoselective Reduction of Pyridines to Tetra...

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Development of a scaleable route for the production of cis-N...

[Brown Ripin, David H.; Abele, Stefan; Cai, Weiling; Blumenkopf, Todd; Casavant, Jeffrey M.; Doty, Jonathan L.; Flanagan, Mark; Koecher, Christian; Laue, Klaus W.; McCarthy, Keith; Meltz, Cliff; Munchhoff, Mike; Pouwer, Kees; Shah, Bharat; Sun, Jianmin; Teixeira, John; Vries, Ton; Whipple, David A.; Wilcox, Glenn Organic Process Research and Development, 2003 , vol. 7, # 1 p. 115 - 120]

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