Synthesis and Antimicrobial Properties of 1-(3, 4-Dichlorophenyl) cycloalkyl-1-penicillins and Cephalosporins

…, SL Mndzhoyan, YZ Ter-Zakharyan…

Index: Akopyan; Martirosyan; Mndzhoyan; Ter-Zakharyan; Kazaryan; Aleksanyan Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 8 p. 421 - 423

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Abstract

Based on the mathematical (QSAR) predictions for 1-arylcycloalkyl-1-penicillins, we may expect that introduction of substituents such as F, Cl, and OH into the aromatic nucleus of these compounds may lead to derivatives possessing lower toxicity and higher acid resistance [1, 2]. Previously [3], we synthesized semisynthetic penicillins and cephalosporins with Cl and Br substituents in ortho, meta, and para positions of the aromatic ring; the ...