Antifreeze Protein??Induced Selective Crystallization of a New Thermodynamically and Kinetically Less Preferred Molecular Crystal

S Wang, X Wen, JA Golen, JF Arifin…

Index: Wang, Sen; Wen, Xin; Golen, James A.; Arifin, Josh F.; Rheingold, Arnold L. Chemistry - A European Journal, 2013 , vol. 19, # 47 p. 16104 - 16112

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Abstract

Abstract The formation of a new, dihydrate crystalline form of 5-methyluridine (m 5 U) was selectively induced by a protein additive, antifreeze protein (AFP) in a highly efficient manner (in 10− 6 molar scale, whereas known kinetic additives need 0.1 molar scale). The hemihydrate form (form I, the only previously known crystalline form of m 5 U) and the dihydrate form of m 5 U (form II) obtained herein were characterized using X-ray ...