Australian Journal of Chemistry

Synthesis of casein-related peptides and phosphopeptides. X. A modified method for the synthesis of Ser (P)-containing peptides through 4-bromobenzyl phosphate …

JW Perich, RB Johns

Index: Perich, John W.; Johns, R. B. Australian Journal of Chemistry, 1991 , vol. 44, # 3 p. 389 - 396

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Citation Number: 25

Abstract

Abstract The three 4-halobenzyl phosphoramidite reagents di (4-fluorobenzyl) N, N- diisopropylphosphor-amidite, di (4-chlorobenzyl) N, N-diisopropylphosphoramidite and di (4- bromobenzyl) N, N-diethylphosphoramidite were prepared and used for the efficient phosphite-triester phosphorylation of isobutyl alcohol. While all three 4-halobenzyl groups were cleaved at similar rates from the 4-halobenzyl phosphorotriesters by 4 M HCl/dioxan ...