Tetrahedron letters

Derivatives of pentamidine designed to target the Leishmania lipophosphoglycan

KL Kramp, K DeWitt, JW Flora, DC Muddiman…

Index: Kramp, Kari L.; DeWitt, Kristin; Flora, Jason W.; Muddiman, David C.; Slunt, Kelli M.; Houston, Todd A. Tetrahedron Letters, 2005 , vol. 46, # 4 p. 695 - 698

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Citation Number: 15

Abstract

The Leishmania lipophosphoglycan (LPG) is the most abundant cell surface glycoconjugate of a family of infectious protozoa. Pentamidine, a common drug used in the treatment of Leishmania infections, has been modified with boronic acids so that it might bind more selectively to the phosphodisaccharide repeating unit of the LPG. This could serve to target the drug to the protozoan surface and increase its efficacy in vivo.