Synthesis of New Benzoxazinone Derivatives as Neuropeptide Y5 Antagonists for the Treatment of Obesity#

A Torrens, J Mas, A Port, JA Castrillo…

Index: Journal of Medicinal Chemistry, , vol. 48, # 6 p. 2080 - 2092

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Citation Number: 8

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. As a result of the screening of the NPY Y5 receptor performed with our internal compound collection, benzoxazinone 5f (Chart 2) was identified as a hit displaying moderate binding affinity (IC 50 = 300 nM). ...

Development of orally active oxytocin antagonists: studies o...

[Bell, Ian M.; Erb, Jill M.; Freidinger, Roger M.; Gallicchio, Steven N.; Guare, James P.; Guidotti, Maribeth T.; Halpin, Rita A.; Hobbs, Doug W.; Homnick, Carl F.; Kuo, Michelle S.; Lis, Edward V.; Mathre, David J.; Michelson, Stuart R.; Pawluczy, Joseph M.; Pettibone, Douglas J.; Reiss, Duane R.; Vickers, Stanley; Williams, Peter D.; Woyden, Carla J. Journal of Medicinal Chemistry, 1998 , vol. 41, # 12 p. 2146 - 2163]