Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway

…, S Mukherjee, WA van der Donk

Index: Bougioukou, Despina J.; Mukherjee, Subha; Van Der Donk, Wilfred A. Proceedings of the National Academy of Sciences of the United States of America, 2013 , vol. 110, # 27 p. 10952 - 10957

Full Text: HTML

Citation Number: 14

Abstract

Abstract Bioactive natural products containing a CP bond act as mimics of phosphate esters and carboxylic acids, thereby competing with these compounds for active sites of enzymes. Dehydrophos (DHP), a broad-spectrum antibiotic, is a phosphonotripeptide produced by Streptomyces luridus, in which glycine and leucine are linked to an aminophosphonate analog of dehydroalanine, ΔAla (P). This unique feature, in combination with the ...