e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
The α-effect in iminium ion catalysis
JL Cavill, RL Elliott, G Evans, IL Jones, JA Platts…
Index: Cavill, Julie L.; Elliott, Richard L.; Evans, Gareth; Jones, Ian L.; Platts, James A.; Ruda, Antonio M.; Tomkinson, Nicholas C. O. Tetrahedron, 2006 , vol. 62, # 2-3 p. 410 - 421
The α-effect can be used as an effective means to promote iminium ion catalysed transformations, providing acyclic scaffolds to aid in catalyst design. A thorough investigation of the structure–activity relationship of the catalyst architecture reveals optimal substituents of a disubstituted carbamate and a secondary alkyl group around a hydrazine scaffold. Molecular modelling investigations provide a mechanistic rationale to the results observed.
