The direct asymmetric catalytic aldol reaction is one of the most important carbon–carbon bond forming reactions, and excellent results for it have recently been published; [6] and [7] one of which is an elegant, proline-mediated aldol reaction between acetone and aldehydes, by List and co-workers 7 As the reaction is synthetically useful, we applied our high pressure system to it, expecting a higher enantioselectivity due to the lower reaction temperature, which ...
