Molecules

Copper-catalyzed N-arylation of amides using (S)-N-methylpyrrolidine-2-carboxylate as the ligand

C Wang, L Liu, W Wang, DS Ma, H Zhang

Index: Wang, Chaoyu; Liu, Lijuan; Wang, Wei; Ma, Dong-Sheng; Zhang, Hua Molecules, 2010 , vol. 15, # 3 p. 1154 - 1160

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Citation Number: 19

Abstract

Abstract (S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields. Keywords:

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