Synlett

Cis-dihydroxylation of alkenes by a non-heme iron enzyme mimic

SM Barry, PJ Rutledge

Index: Barry, Sarah M.; Rutledge, Peter J. Synlett, 2008 , # 14 p. 2172 - 2174

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Citation Number: 4

Abstract

Using the non-heme iron oxidase active site as a template, a peptidomimetic ligand has been designed, synthesized, and used to effect the dihydroxylation of alkene substrates. Fenton-type radical pathways are also observed. ... Nature uses a diverse range of iron-based enzyme systems to effect the oxidation of hydrocarbon substrates with remarkable efficiency and exquisite control. [¹-³] These include the porphyrin-based cytochrome P450s, [¹] the soluble di-iron ...