Tetrahedron

The synthesis of PGF 1 α by re-structuring of castor oil

D Ranganathan, S Ranganathan, MM Mehrotra

Index: Ranganathan, D.; Ranganathan, S.; Mehrotra, M. M. Tetrahedron, 1980 , vol. 36, p. 1869 - 1876

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Citation Number: 18

Abstract

Castor oil has been transformed—via methyl ricinoleate—to PGF1α by strategy wherein 16 of the 18 carbons of the castor oil backbone are incorporated in the C-20 PGF1α, involving, inter alia, a novel procedure for the regiospecific functionalisation of terminal olefins, a novel degradation of aldehyde to lower acid and strategies useful for the generation of the highly functionalised prostanoid system, which specially illustrate the utility of MEM protecting ...