Bioorganic & medicinal chemistry

Synthesis, characterization and antitumor studies of Mn (II), Fe (III), Co (II), Ni (II), Cu (II) and Zn (II) complexes of N-salicyloyl-N′-o-hydroxythiobenzhydrazide

A Shrivastav, NK Singh, SM Singh

Index: Shrivastav, Anuraag; Singh, Nand K.; Singh, Sukh Mahendra Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 4 p. 887 - 895

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Citation Number: 26

Abstract

A new ligand N-salicyloyl-N′-o-hydroxythiobenzhydrazide (H2Sotbh) forms complexes [Mn (HSotbh) 2],[Fe (Sotbh-H)(H2O) 2],[M (Sotbh)][M= Co (II), Cu (II) and Zn (II)] and [Ni (Sotbh)(H2O) 2], which were characterized by various physico-chemical techniques. Mössbauer spectrum of [Fe (Sotbh-H)(H2O) 2] reveals the quantum admixture of 5/2 and 3/2 spin-states. Mn (II), Cu (II) and Ni (II) complexes were observed to inhibit the growth of ...