Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors

…, F Shirazi, M Razdan, P Nimkar, SP Maybhate…

Index: Chaudhary, Preeti M.; Chavan, Sayalee R.; Shirazi, Fazal; Razdan, Meenakshi; Nimkar, Prachi; Maybhate, Shailaja P.; Likhite, Anjali P.; Gonnade, Rajesh; Hazara, Braja G.; Deshpande, Mukund V.; Deshpande, Sunita R. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2433 - 2440

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Citation Number: 46

Abstract

Click reaction approach toward the synthesis of two sets of novel 1, 2, 3-triazolyl linked uridine derivatives 19a–19g and 21a–21g was achieved by Cu (I)-catalyzed 1, 3-dipolar cycloaddition of 5′-azido-5′-deoxy-2′, 3′-O-(1-methylethylidene) uridine (17) with propargylated ether of phenols 18a–18g and propargylated esters 20a–20g. Structure of one of the representative compound 19d was unambiguously confirmed by X-ray ...