Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies

…, L Zhang, L Chen, K Cheng, M Zheng, X Wen…

Index: Liang, Zhongjie; Zhang, Liying; Li, Lianchun; Liu, Jun; Li, Hongling; Zhang, Luyong; Chen, Limin; Cheng, Keguang; Zheng, Mingyue; Wen, Xiaoan; Zhang, Pu; Hao, Jia; Gong, Yanchun; Zhang, Xia; Zhu, Xiaoyun; Chen, Jun; Liu, Hong; Jiang, Hualiang; Luo, Cheng; Sun, Hongbin European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2011 - 2021

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Citation Number: 25

Abstract

Naturally occurring pentacyclic triterpenes (PT), a novel class of inhibitors against glycogen phosphorylase (GP), hold promise for the treatment of type-2 diabetes and other diseases with disorders in glycogen metabolism. To identify novel and more potent GP inhibitors, the receptor-based comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) approaches were performed to investigate the quantitative ...