Asymmetric synthesis catalyzed by chiral ferrocenylphosphine-transition metal complexes. 5. Palladium-catalyzed asymmetric allylation of active methine compounds

…, K Kanehira, T Hagihara, M Kumada

Index: Hayashi, Tamio; Kanehira, Koichi; Hagihara, Toshiya; Kumada, Makoto Journal of Organic Chemistry, 1988 , vol. 53, # 1 p. 113 - 120

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Citation Number: 169

Abstract

Catalytic asymmetric allylation of sodium enolates of 0-diketones with allyl acetate proceeded with high enantioselectivity in the presence of 0.5-1.0 mol% of palladium complexes as catalysts bearing functionalized chiral ferrocenylphosphine ligands, giving optically active ketones with a chiral quaternary carbon center. The most effective ligand was (R)-N-methyl-N-(2-hydroxyethyl)-l-[(S)-1', 2-bis (diphenylphosphino) ferrocenyl] ...