Summary: A six-step synthesis of (f bcamptothecin has been achieved starting from 2-methoxypyridine and 2-bromoquinoline. The antitumor alkaloid camptothecin (1) has attracted much attention over the years since its isolation in 1966.' Camptothecin has a long, rich history1v2 as a potential anticancer agent, and it has recently reemerged as one of the most important lead compounds among the anti- tumor natural products. Several syntheses of camptoth-
![1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy- Structure](https://image.chemsrc.com/caspic/436/31456-25-4.png)