On the Trityl Method for Peptide Synthesis1

GC Stelakatos, DM Theodoropoulos…

Index: Stelakatos et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 2884,2887

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Citation Number: 50

Abstract

Trityl diriv: itives of atiiiiio xiti. can be simply aiid iffectively isolated b!-cliloroforiu extraction of their diethvlainmonium salts fr (m the tritylation reaction mixturr. S, N'-Ditrit~-l-~-histidi~~ e, S- trityl-L-histidine, S'-trityl-L-liistidiiic, methyl ester hvdr (ichloridc, 0-tritl-IL-tyrosine benzyl ester h>-tlrochloride, amongst other tritylamino acids, were prepared. Coupling (if tritj. lamino acids; md trityldipeptides with amino acid esters was achieved aia the carbodiimidc ...