Tetrahedron Letters

Preparation of copper (II) oxide bound on polystyrene beads and its application in the aryl aminations: synthesis of Imatinib

Y Heo, D Hyun, MR Kumar, HM Jung, S Lee

Index: Heo, Yumi; Hyun, Dajung; Kumar, Manian Rajesh; Jung, Hyun Min; Lee, Sunwoo Tetrahedron Letters, 2012 , vol. 53, # 49 p. 6657 - 6661

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Citation Number: 4

Abstract

CuO nanoflakes bound on polystyrene beads (PS-CuO) were prepared through the oxidation of copper (I) bromide in a suspension of polystyrene. The use of PS-CuO as a catalyst in the presence of KOtBu in the coupling reactions of aryl bromides and amines afforded the coupled products with a yield range of 15–89%. This catalytic system also afforded the key fragment in good yield for the synthesis of Imatinib (Gleevec).