The introduction of the allyl group into the barbituric acid nucleus at the 5-position has led to the production of several therapeutically useful barbituric acids. Barbituric acids containing unsaturated aliphatic groups such as the crotyl, propinyl, cyclohexenyl, and cyclopentenyl groups are known. Shonle and Waldo'found that alkenyl ethyl barbituric acids containing the secondary pentenyl and hexenyl groups not only had less hypnotic action than the ...
