Nitro derivatives of bi-and tri-cyclic heterocycles as potential radio-sensitizers

J Yizun, GE Adams, J Parrick, IJ Stratford

Index: Yizun, Jin; Adams, Gerald E.; Parrick, John; Stratford, Ian J. European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 511 - 516

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Citation Number: 3

Abstract

Abstract Two series of bicyclic compounds having a pyridinic and pyrrolic nitrogen atom in different rings have been synthesized as potential radiosensitizers of hypoxic mammalian cells. The compounds were obtained from 3-nitro-pyrrolo [2, 3-b] pyridine by regioselective alkylation at the nitrogen atom in either the 5-or 6-membered rings. Partition coefficients, one electron reduction potentials, radiosensitization of Chinese hamster V79 cells and ...