… and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent: benzothiazol-2-one 7- …

J Weinstock, DE Gaitanopoulos…

Index: Weinstock, Joseph; Gaitanopoulos, Dimitri E.; Stringer, Orum D.; Franz, Robert G.; Hieble, J. Paul; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 7 p. 1166 - 1176

Full Text: HTML

Citation Number: 45

Abstract

Our interest in identifying D-1 and D-2 dopamine receptor agonists that are not catechols led us to extend previous studies with oxindoles by investigating analogues of dopamine, N, N- dipropyldopamine, m-tyramine, N, N-dipropyl-m-tyramine, and epinine in which the m- hydroxyl is replaced by the NH portion of a thiazol-2-one, oxazol-2-one, or imidazol-2-one group fused to the 2, 3-position. These compounds were evaluated for their affinity and ...