Science

Taming of fluoroform: direct nucleophilic trifluoromethylation of Si, B, S, and C centers

GKS Prakash, PV Jog, PTD Batamack, GA Olah

Index: Surya Prakash; Jog, Parag V.; Batamack, Patrice T. D.; Olah, George A. Science, 2012 , vol. 338, # 6112 p. 1324 - 1327

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Citation Number: 132

Abstract

Abstract Fluoroform (CF 3 H), a large-volume by-product of the manufacture of Teflon, refrigerants, polyvinylidene fluoride (PVDF), fire-extinguishing agents, and foams, is a potent and stable greenhouse gas that has found little practical use despite the growing importance of trifluoromethyl (CF3) functionality in more structurally elaborate pharmaceuticals, agrochemicals, and materials. Direct nucleophilic trifluoromethylation using CF 3 H has ...