Tetrahedron

Efficient synthesis of 2, 4-disubstituted thiazoles using ionic liquid under ambient conditions: a practical approach towards the synthesis of Fanetizole

TM Potewar, SA Ingale, KV Srinivasan

Index: Potewar, Taterao M.; Ingale, Sachin A.; Srinivasan, Kumar V. Tetrahedron, 2007 , vol. 63, # 45 p. 11066 - 11069

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Citation Number: 87

Abstract

A highly efficient and rapid synthesis of 2-amino-4-arylthiazoles and 2-methyl-4-arylthiazole from α-bromoketone and thiourea/thioamide is described using room temperature ionic liquid at ambient conditions. The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. This protocol is utilized for a commercially feasible synthesis of an anti-inflammatory agent, Fanetizole.