Efficient Synthesis of 2??Aminothiazoles and Fanetizole in Liquid PEG??400 at Ambient Conditions

PY Lin, RS Hou, HM Wang, IJ Kang…

Index: Lin, Pei-Ying; Hou, Rei-Sheu; Wang, Huey-Min; Kang, Iou-Jiun; Chen, Ling-Ching Journal of the Chinese Chemical Society, 2009 , vol. 56, # 3 p. 455 - 458

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Citation Number: 19

Abstract

Abstract A simple and practical procedure for the synthesis of 2-aminothiazoles from α- tosyloxyketones and thioureas is described using PEG-400 [poly (ethylene glycol-400)] at ambient conditions. The developed protocol is successfully applied for the preparation of an anti-inflammatory drug, Fanetizole.