Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors

…, A Defoin, E Salomon, C Tarnus, A Wetterholm…

Index: Albrecht, Sebastien; Defoin, Albert; Salomon, Emmanuel; Tarnus, Celine; Wetterholm, Anders; Haeggstroem, Jasper Z. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7241 - 7257

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Citation Number: 20

Abstract

Racemic derivatives of 3-amino-2-tetralone were synthesised and evaluated for their ability to inhibit metallo-aminopeptidase activities. New compounds substituted in position 2 by methyl ketone, substituted oximes or hydroxamic acids as well as heterocyclic derivatives were evaluated against representative members of zinc-dependent aminopeptidases: leucine aminopeptidase (EC 3.4. 11.1), aminopeptidase-N (EC 3.4. 11.2), Aeromonas ...