Synthesis

Complete regioselectivity in staurosporine chromophore formation

S Eils, E Winterfeldt

Index: Eils, Stefan; Winterfeldt, Ekkehard Synthesis, 1999 , # 2 p. 275 - 281

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Citation Number: 15

Abstract

Abstract: For the preparation of regioselectively N-substituted indolocarbazole alkaloids two strategies have been employed: 1. the exploitation of different electronic situations at the nitrogen atoms, and 2. the utilization of an orthogonal protecting group strategy that allows regioselective glycoside formation. Keywords: indolecarbazole glycosides; regioselectivity; orthogonal protecting groups; N-glycosylation; PKC inhibitors

~57%

Synthesis of N-protected staurosporinones

[Wada, Yasuhiro; Nagasaki, Hideo; Tokuda, Masao; Orito, Kazuhiko Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2008 - 2014]

Synthetic studies on indolocarbazoles: Total synthesis of st...

[Rajeshwaran, Ganesan Gobi; Mohanakrishnan, Arasambattu K Organic Letters, 2011 , vol. 13, # 6 p. 1418 - 1421]

Synthesis of N-protected staurosporinones

[Journal of Organic Chemistry, , vol. 72, # 6 p. 2008 - 2014]