Tetrahedron Letters

Candida antarctica lipase B-catalyzed synthesis of acetamides using [BMIm (PF 6)] as a reaction medium

KP Dhake, ZS Qureshi, RS Singhal, BM Bhanage

Index: Dhake, Kishor P.; Qureshi, Ziyauddin S.; Singhal, Rekha S.; Bhanage, Bhalchandra M. Tetrahedron Letters, 2009 , vol. 50, # 23 p. 2811 - 2814

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Citation Number: 43

Abstract

An efficient protocol has been developed for synthesis of acetamides using Candida antarctica lipase B (CaL B) in [BMIm (PF6)] as a greener reaction medium. The reaction is applicable to a wide variety of aliphatic esters/acetic acid and amines providing excellent yields of corresponding acetamide. The catalyst exhibits remarkable activity and is reusable for up to four consecutive cycles.