Abstract A series of heterocyclic derivatives analogous to (−) vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4–O, C4–S or C4–N were used as the sites of attachment. The 4-[3-(1-piperidyl) propylsulfanyl] derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in ...
