Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives

YJ Yang, YN Yang, JS Jiang, ZM Feng, HY Liu…

Index: Yang, Ya Jun; Yang, Ya Nan; Jiang, Jian Shuang; Feng, Zi Ming; Liu, Hong Yan; Pan, Xian Dao; Zhang, Pei Cheng Chinese Chemical Letters, 2010 , vol. 21, # 8 p. 902 - 904

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Citation Number: 15

Abstract

A series of heterocycle-substituted phthalimide derivatives were synthesized. Structurally diverse derivatives with heterocyclic rings, including furan, imidazo [1, 2-a] pyridine, 1, 3, 4- thiadiazine, imidazo [2, 1-b][1, 3, 4] thiadiazine, pyrazole, 1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazine, thiazole and thiazoline, were obtained by the reactions of α-bromoketone intermediate with various nucleophiles containing oxygen, nitrogen and sulfur atom. Their ...