Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors

S Kang, HJ Min, MS Kang, MG Jung, S Kim

Index: Kang, Sunghyun; Min, Hye-Jin; Kang, Min-Seo; Jung, Myung-Geun; Kim, Semi Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1748 - 1751

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Citation Number: 13

Abstract

TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2- hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated ...