Synthesis of fused polycycles by 1, 4-palladium migration chemistry

Q Huang, MA Campo, T Yao, Q Tian…

Index: Campo, Marino A.; Huang, Qinhua; Yao, Tuanli; Tian, Qingping; Larock, Richard C. Journal of the American Chemical Society, 2003 , vol. 125, # 38 p. 11506 - 11507

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Citation Number: 76

Abstract

Novel palladium migration/arylation methodology for the synthesis of complex fused polycycles has been developed, in which one or more sequential Pd-catalyzed intramolecular migration processes involving CH activation are employed. The chemistry works best with electron-rich aromatics, which is in agreement with the idea that these palladium-catalyzed CH activation reactions parallel electrophilic aromatic substitution.