Convenient Synthesis of 2-Allyl-3-bromo-1, 4-dimethoxynaphthalene: Key Intermediate as Building Block for Bioactive Pyranonaphthoquinones

RA Limaye, P Gaur, MV Paradkar…

Index: Limaye, Rohan A.; Gaur, Pinki; Paradkar, Madhusudan V.; Natu, Arun D. Synthetic Communications, 2012 , vol. 42, # 3 p. 313 - 319

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Citation Number: 4

Abstract

The majority of synthetic strategies for the pyranonaphthoquinones involve building the pyran system on a suitably substituted naphthalene ring by various methodologies, followed by oxidation of the naphthopyran, thereby generating the desired pyranonaphthoquinone. It was therefore quite logical that a system with suitable substituents at the desired positions on naphthalene core is of utmost importance. For example, a synthon 2-allyl-3-bromo-1,4- ...