Novel polycyclic heterocycles. Derivatives of 5, 11-dihydrodibenz [b, e][1, 4] oxazepine and 5, 11-dihydrodibenzo [b, e][1, 4] thiazepine

HL Yale, B Beer, J Pluscec…

Index: Yale,H.L. et al. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 713 - 722

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Citation Number: 16

Abstract

A number of &substituted 3, 11-dihydrodibenz [b, e][1, 4] oxazepines and 5, ll- dihydrodibenzo [b, e][1, 4] thiazepines have been prepared. When the 5-substituent is 3-[1- (2-hpdroxyethyl)-4-piperazinyl] propyl and a sitbstituent like C1 or CFa is in the 3, or 7 position, the compounds show antianxiety effects at lower duses and CXS depressant activity at higher doses. When the 5 substituent is a simple dialkylaminoalkyl group, then ...