Journal of the American Chemical Society

New Photoactivated Protecting Groups. 6. p-Hydroxyphenacyl: A Phototrigger for Chemical and Biochemical Probes1, 2

CH Park, RS Givens

Index: Park, Chan-Ho; Givens, Richard S. Journal of the American Chemical Society, 1997 , vol. 119, # 10 p. 2453 - 2463

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Citation Number: 197

Abstract

p-Hydroxyphenacyl, a new photoactive, aqueous soluble protecting group is proposed as a second generation α-keto “cage” reagent, a phototrigger for the efficient, rapid release of bioactive phosphates, eg, inorganic phosphate (Pi) and ATP (Givens, RS; Park, C.-H. Tetrahedron Lett. 1996, 37, 6259-6262). p-Hydroxyphenacyl esters 6c and 7 trigger the release of Pi and ATP when irradiated at wavelengths between 300-350 nm also yielding ...