Synlett

Heck reaction in water with amphiphilic resin-supported palladium-phosphine complexes

Y Uozumi, T Kimura

Index: Uozumi, Yasuhiro; Kimura, Tsutomu Synlett, 2002 , # 12 p. 2045 - 2048

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Citation Number: 73

Abstract

We have examined several polymer supports and phosphine units for the Heck reaction of iodobenzene (1a) and acrylic acid (2) (Table [1] ). Reaction of 1a with 2 in water in the presence of a supported palladium catalyst and base at 25 °C for 20 hours gave cinnamic acid (3a), which was extracted with aqueous alkaline during the reaction. The reaction mixture was filtered and the catalyst resin was rinsed with a small portion of saturated sodium bicarbonate. The aqueous filtrate was ...