The embryogenesis of a multicellular organism relies on the spatiotemporal control of the concentrations of signaling molecules and the way cells respond to them.[1] One of these, retinoic acid (RA), plays a key role in patterning the body axis and in the formation of many organs.[2] RA concentration is finely regulated both spatially and temporally and its alteration results in developmental defects. An ability to artificially tune the RA ...
[Wells, Geoffrey; Suggitt, Marie; Coffils, Marissa; Baig, Mirza A.H.; Howard, Philip W.; Loadman, Paul M.; Hartley, John A.; Jenkins, Terence C.; Thurston, David E. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 2147 - 2151]
