Synthesis

Indium (III) halides as new and highly efficient catalysts for N-tert-butoxycarbonylation of amines

SV Chankeshwara, AK Chakraborti

Index: Chankeshwara, Sunay V.; Chakraborti, Asit K. Synthesis, 2006 , # 16 p. 2784 - 2788

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Citation Number: 33

Abstract

Abstract Indium (III) bromide and chloride efficiently catalysed the N-tert-butoxycarbonylation of amines with (Boc) 2 O at room temperature and under solvent-free conditions. Various aromatic, heteroaromatic and aliphatic amines were converted to N-tert-butylcarbamates in excellent yields in short times. Chiral amines, esters of α-amino acids and β-amino alcohols afforded optically pure Nt-Boc derivatives in high yields. The reactions were ...