Abstract The preparation of the potassium channel opener (3 S, 4 R)??3, 4??dihydro??4??(2, 3?? dihydro??2??methyl??3??oxo??pyridazin??6??yl) oxy??3??hydroxy??6??(3??hydroxyphenyl) sulphonyl??2, 2, 3??trimethyl??2H??benzo [b] pyran (1) as a single enantiomer is reported. Considerable improvements have been implemented with respect to the original synthesis that allow for the preparation of multigram quantities of the final target compound. The optimized ...
