Selective metal-catalyzed autoxidation of 2-arylpropionaldehydes. An improved synthesis of ibuprofen

…, DP Getman, GR Beck, RM Heintz

Index: Riley; Getman; Beck; Heintz Journal of Organic Chemistry, 1987 , vol. 52, # 2 p. 287 - 290

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Citation Number: 32

Abstract

1-(4-Isobutylphenyl) ethanol? Under Nz atmosphere, a diethyl ether solution containing 5.3 g of 4ispbutylphenyl methyl ketone was added dropwise with stirring to a diethyl ether solution containing 3.25 g of LiAIHI. After the addition, the mixture was refluxed for 1 h. The treatment of the reaction with HzO (3.25 mL) and then base (3.25 mL, 15% NaOH) and HzO (10 mL) gave a precipitate which was separated by filtration. The ether filtrate was dried ...