Modified taxols. 3. Preparation and acylation of baccatin III

…, DGI Kingston, C Jitrangsri, T Piccariello

Index: Magri, Neal F.; Kingston, David G.I.; Jitrangsri, Chote; Piccariello, Thomas Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3239 - 3242

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Citation Number: 62

Abstract

In the previous paper in this series we discussed various oxidation reactions of taxol la and the products resulting therefrom.'In this paper we turn our attention to the preparation and reactions of baccatin I11 (2), the diterpenoid nucleus of taxol. A key component of our studies on structure-activity relationships in the taxol area is the preparation of taxol analogues with modified C-13 ester side chains. One way of preparing these analogues is ...

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Total synthesis of baccatin III and taxol

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