Asymmetric Total Synthesis of Taxol\ R

T Mukaiyama, I Shiina, H Iwadare…

Index: Shiina, Isamu; Iwadare, Hayato; Sakoh, Hiroki; Hasegawa, Masatoshi; Tani, Yu-Ichirou; Mukaiyama, Teruaki Chemistry Letters, 1998 , # 1 p. 1 - 2

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Citation Number: 263

Abstract

Abstract A new method for the total asymmetric synthesis of antitumor agent Taxol is described. Baccatin III, a complex carbon framework, is synthesized by way of B to BC to ABC ring construction. Further, a method of forming Taxol from baccatin III and a β-amino acid is also demonstrated.

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Total synthesis of baccatin III and taxol

[Danishefsky, Samuel J.; Masters, John J.; Young, Wendy B.; Link; Snyder, Lawrence B.; Magee, Thomas V.; Jung, David K.; Isaacs, Richard C. A.; Bornmann, William G.; Alaimo, Cheryl A.; Coburn, Craig A.; Di Grandi, Martin J. Journal of the American Chemical Society, 1996 , vol. 118, # 12 p. 2843 - 2859]

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Enantioselective Synthesis of the Excitatory Amino Acid (1 S...

[Shiina, Isamu; Saitoh, Masahiro; Nishimura, Koji; Saitoh, Katsuyuki; Mukaiyama, Teruaki Chemistry Letters, 1996 , # 3 p. 223 - 224]

Asymmetric Total Synthesis of Taxol\ R

[Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161]