From Difluoromethyl 2??Pyridyl Sulfone to Difluorinated Sulfonates: A Protocol for Nucleophilic Difluoro (sulfonato) methylation

GK Prakash, C Ni, F Wang, J Hu…

Index: Prakash, G. K. Surya; Ni, Chuanfa; Wang, Fang; Hu, Jinbo; Olah, George A. Angewandte Chemie - International Edition, 2011 , vol. 50, # 11 p. 2559 - 2563

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Citation Number: 28

Abstract

Fluorine, characterized by its small size and high electronegativity, often furnishes organic molecules with unequalled chemical and biological properties including stability, lipophilicity, and bioavailability.[1] The sulfonic acid functional group has not only found its use in modern materials such as proton-exchange membranes and surfactants,[2] but also in synthetic molecules with important biological and pharmacological activities such as ...