Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling

M Artico, R Di Santo, R Costi, E Novellino…

Index: Journal of Medicinal Chemistry, , vol. 41, # 21 p. 3948 - 3960

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Citation Number: 168

Abstract

... Journal of Medicinal ... Notable exceptions are l-chicoric acid and some dicaffeoylquinic acids isolated from Bolivian medicinal plants which, in addition to being very potent and specific IN inhibitors in enzyme assays, inhibit the HIV-1 multiplication in acutely infected ... Chemistry. ...

1, 5-Diphenyl-1, 4-pentadiene-3-ones and cyclic analogues as...

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Synthesis and anti-inflammatory activities of mono-carbonyl ...

[Liang, Guang; Li, Xiaokun; Chen, Li; Yang, Shulin; Wu, Xudong; Studer, Elaine; Gurley, Emily; Hylemon, Phillip B.; Ye, Faqing; Li, Yueru; Zhou, Huiping Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 4 p. 1525 - 1529]

Anti-oxidant activities of curcumin and related enones

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