Journal of medicinal chemistry

Potential antitumor agents. 27. Quantitative structure-antileukemic (L1210) activity relationships for the. omega.[4-(9-acridinylamino) phenyl] alkanoic acids

WA Denny, BF Cain

Index: Denny,W.A.; Cain,B.F. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 430 - 437

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Citation Number: 35

Abstract

acetonitrile (350 mL). The solution was stirred for 3 days at room temperature. The solvent was evaporated and the residue was dissolved in a minimum amount of CHC1, and chromatographed on a silica gel column [eluent, acetone-CHC1,(1: 9)]. The fractions containing the glycosylation product were pooled, evaporated to dryness, and treated with MeOH (400 mL), presaturated with NH3 at 0" C. The solution was stored in a pressure ...